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Research from King’s College London, published 9 February 2026 in Clinical Toxicology, suggests deaths linked to potent synthetic opioids known as nitazenes have been undercounted in the United Kingdom by up to one-third.
Laboratory tests using anaesthetised animal models and simulations of routine pathology handling found on average only 14% of nitazene present at the time of overdose remained detectable in post-mortem blood samples, raising concerns that standard toxicology misses many cases.
The study applied modelling to National Programme on Substance Use Mortality data and identified a roughly 33% excess in unexplained drug deaths in Birmingham in 2023 that could be consistent with non-detection.
Nitazenes can be up to 500 times more potent than heroin and have become more common on the unregulated market.
Officials reported hundreds of synthetic-opioid linked deaths in recent reporting periods; the researchers warn that current mortality figures and harm-reduction policies may therefore be based on incomplete data, limiting their effectiveness.






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