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Multiple outlets reported that actress Christina Applegate, 54, has been hospitalized in Los Angeles since late March, citing a TMZ report.
Applegateâs representative declined to confirm hospitalization or provide medical details, saying only that she has âa long history of complicated medical conditionsâ and has been open about them in her memoir and podcast.
Applegate, who publicly revealed a multiple sclerosis (MS) diagnosis in 2021, released her memoir You With the Sad Eyes on March 3, 2026, and cohosts the MeSsy podcast with JamieâLynn Sigler, who announced a brief podcast hiatus on March 31 for book tours.
Applegate has previously described severe symptoms, frequent hospital visits (she has said she was hospitalized âupwards of 30 timesâ over three years) and complications including a double kidney infection.
In recent interviews and excerpts she has spoken candidly about bed confinement, chronic pain, depression and the emotional toll of MS. Reports do not specify whether the current hospital stay is directly linked to MS, and her team has not provided further information.
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Readers add clinical context: severe MS relapses often require hospital care and can leave lasting deficits, while immunosuppressive treatments raise infection and GI risks. Emerging therapies like HSCT and CARâT offer hope but carry significant risks and timelines for wider availability.








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