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A multinational team led by researchers at the Max Planck Institute of Animal Behavior and the University of Bonn reports that homing pigeons may use iron-laden immune cells in their livers as a magnetic compass.
Published May 28 in Science, the study found millions of ferritin-rich macrophages clustered near nerve fibers in pigeon livers.
In behavioural trials, 34 trained pigeons were taken 19 kilometres from their home and released on overcast days after half the birds received a treatment that transiently depletes liver macrophages.
Birds with intact macrophages homed in roughly 70 minutes; treated birds became disoriented and did not reliably return until sunlight reappeared.
The work complements earlier hypotheses involving eye proteins or beak magnetite by identifying a different, unexpected tissue and offers a mechanistic linkāiron-filled immune cellsāthat could transduce magnetic information to the nervous system.
Authors note important gaps remain, including how macrophage signals reach the brain and whether other species share the same system.
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