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A University of Edinburgh study mapping genetic risk across the British Isles finds the highest prevalence of the C282Y variant—the main genetic risk factor for hereditary haemochromatosis, often called the “Celtic curse”—in the north‑west of Ireland (about 1 in 54 people). Researchers analysed genetic data from more than 400,000 participants in UK Biobank and Viking Genes across 29 regions and report elevated rates in the Outer Hebrides (1 in 62) and Northern Ireland (1 in 71), with mainland Scots also at increased risk.
The team cross‑checked NHS England records and identified more than 70,000 diagnosed cases, noting diagnoses were nearly four times higher among white Irish than white British patients and that people from Liverpool had 11 times the diagnosis rate of those from Kent.
The authors and Haemochromatosis‑UK call for targeted, community‑level genetic screening in identified hotspots to improve early detection and use simple interventions such as regular phlebotomy to prevent organ damage.
The study is published in Nature Communications and was carried out with RCSI and Haemochromatosis‑UK.
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Irish IndependentHealthRisk of carrying the ‘Celtic curse’ gene varies across Ireland, new study finds
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