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An international team led by University College London and the Allen Institute unveiled Neuropixels Opto on June 1, 2026 in Nature Methods: a silicon neural probe that simultaneously records and manipulates neuronal activity.
The device integrates high-density electrophysiological recording sites with microscopic light emitters along a shaft narrower than a human hair, enabling electrical readout from hundreds of neurons while delivering targeted optogenetic stimulation deep in the brain.
Validated in mice as part of a ÂŁ15 million project funded by the Wellcome Trust, the Allen Institute and partners, Neuropixels Opto overcomes prior technical barriers to combining light delivery and sensitive recordings in deep regions.
Early experiments show surprisingly localised cortical responses and permit direct causal tests of how specific neurons influence surrounding circuits.
Developers say the tool could accelerate circuit mapping, improve study of neurological and psychiatric disorders such as Alzheimer’s, Parkinson’s and schizophrenia, and scale high-resolution neural recording for labs worldwide.








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