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A multinational multicohort study published in The Lancet on Feb. 9, 2026 found that adults with obesity face markedly higher risks of severe infectious disease outcomes.
Pooling data from two Finnish cohorts and the UK Biobank — more than 540,000 people followed for about 13 years on average — researchers report that obesity (BMI ≥30) is associated with a 70% higher risk of hospitalisation or death from a broad set of 925 bacterial, viral, parasitic and fungal infections.
People with the most severe obesity had around three times the risk.
Using global mortality and obesity prevalence data, the authors estimate obesity may have contributed to roughly 0.6 million of 5.4 million infection-related deaths worldwide in 2023 (about 11%), with higher proportions in some countries (around one in six in the UK and one in four in the US). The association persisted after accounting for common chronic conditions and did not appear to extend to severe HIV or tuberculosis.
Study limitations include observational design that cannot prove causality.
Authors and commentators point to immunological mechanisms and suggest weight-management policies, vaccination and equitable access to effective weight-loss therapies could reduce this burden.
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Comments reinforce biologically plausible mechanisms—immune dysregulation and chronic inflammation—explaining higher severe infection risk in obesity, and highlight social drivers (deprivation, food environments) and the diabetes connection, underscoring the need for policy, prevention and care‑delivery adaptations.






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