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A Penn State-led study published in the Journal of Nutrition found diets high in fat — including a ketogenic regimen — caused greater metabolic and liver damage than high-carbohydrate diets in mice.
Over 16 weeks researchers fed mice one of four diets (high-carbohydrate, high-fat, ketogenic or a whole-grain-rich control) while keeping protein at 18% of calories.
The high-fat (40% fat) and ketogenic (81% fat, 1% carbohydrate) groups showed pronounced weight gain (weights doubled), impaired glucose tolerance, early liver injury (evident within two weeks), increased systemic inflammation, higher triglycerides and fat deposits in the liver, plus expression changes linked to scarring.
Mice on the whole-grain chow (57.5% carbohydrates, 13.5% fat) had the healthiest markers.
Diet fats were largely saturated; carbohydrates in experimental diets were mainly refined.
Authors noted fiber supplementation could mitigate harm in some settings and cautioned that human and mouse metabolisms differ, underscoring need for supervised dietary changes.
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Medical News | Medical ArticlesHigh-fat diets cause more damage to metabolic health than carbohydrates
















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