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A team led by Harvard geneticists has found that natural selection altered hundreds of human genes in West Eurasia over the past 10,000–18,000 years, increasing the frequency of traits such as light skin and red hair while reducing others including male-pattern baldness.
Published in Nature on April 15, 2026, the study analysed roughly 15,800 ancient genomes and about 6,400 modern genomes using a new statistical framework (AGES) to detect directional selection through time.
Researchers identified 479 gene variants showing evidence of selection; many map to known traits and disease risks or resistances, including variants associated with coeliac disease, immunity to HIV and leprosy, and reduced rheumatoid arthritis susceptibility.
Some variants rose and later fell in frequency — for example, tuberculosis-related alleles increased until ~3,500 years ago then declined — and the authors report an overall acceleration of directional selection after the transition to farming.
The team has made data and methods publicly available and plans to extend analyses beyond West Eurasia.
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Key takeaways: commentators emphasize that mate choice and negative frequency‑dependent selection could explain rising red‑hair alleles, while MC1R’s known effects on pain/anesthesia show pigmentation genes can have broader physiological impacts; agricultural shifts likely triggered many of the reported selection pulses.







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